The Biopharmaceuticals An Overview Biology Essay

The Biopharmaceuticals An Overview Biology Essay Biopharmaceuticals are defined as proteins and nucleic acids which are used for therapeutic purpose. These are high molecular weight substances prepared by biotechnological means and genetically engineered. Due to their complex structure and intricate molecular composition it is very difficult to characterize and formulate such products. Most of these products are derived from biological species and genetically engineered to produce a potent compound [1-3]. Humulin (biosynthetic recombinant human Insulin) was the first biopharmaceutical product developed by Genentech but licensed and marketed by Eli Lily and Company in 1982. In the modern era biopharmaceutical products have become a major facilitating reason of technological changes in health care sector, causing extraordinary benefits for patients, cost challenges for consumers, and profits for market shareholders.[4] Over the last decade biopharmaceutical market is the fastest growing segment in the pharmaceutical organizations. After post-recession period vigorous advancement has been seen in this area. It has been reported that approximately 40% of total pharmaceutical RD investment is occupied by biopharmaceutical products amongst which, monoclonal antibodies and product produced by recombinant DNA method are the most prevalent one.[5,6] Proteins with different amino acid sequences are the primary structure of such products. For determining the biological activity of a protein it is necessary to study its three-dimensional structure. The structure of protein is generally divided into four categories i.e. primary, secondary, tertiary and quaternary (fig. 1). The primary structure is the sequence of amino acid residues which folds and stabilized by the formation of hydrogen bonds with subsequent molecules in the polypeptide chain to produce an  ÃƒÅ½Ã‚ ± helix,  which is a spiral, rod-like st ructure, or a  ÃƒÅ½Ã‚ ² sheet,  a planar structure. This structure resembles to the secondary structure of proteins. The tertiary structure is a three-dimensional arrangement which gives an overall conformation of a polypeptide chain. Through hydrophobic interactions between the non-polar side chains and disulfide bonds, this tertiary structure is stabilized. A quaternary or multimeric protein contains two or more polypeptide chains, held together by non-covalent bonds.[7] fig 1. Structure of protein. Because of their unique physicochemical characteristic it is very hard and challenging to formulate biopharmaceuticals as products with therapeutic effects and storage characteristics. Meanwhile their formulation is in many ways different from conventional low-molecular drug formulation. Despite of such facts biopharmaceuticals gains lots of attention in the modern era of drug formulation. In the recent reviews it has been discussed that around 400 biotechnology-based medicinal and therapeutic agents are either registered or in the clinical trials are reviewed by the regulatory bodies. These agents are helpful in treating many life threatening diseases some of them are cancer, infectious diseases, autoimmune diseases, and AIDS/HIV. Some of the agents which are already in the market are monoclonal antibodies, recombinant hormones, cytokines, vaccines, recombinant blood factor, and therapeutic enzymes.[5] Discussion Biopharmaceutical market In 1970, discovery of recombinant DNA technology and monoclonal antibodies lead to initiate the development of biopharmaceutical industries. A substantial growth from $8 billion in 1992 to $149 billion in 2010 quenched the thirst of investors towards the biopharmaceutical industry. It is expected to reach $239 billion by 2015 with a growth rate of 9.9% annually. There are more than 400 Biotech drugs and vaccines are scrutinized under clinical stage, targeting more than 200 diseases. Meanwhile a large number of the population is now taking benefits from a number of biotechnological innovations like recombinant protein-based products e.g. monoclonal antibodies and some large molecule prescription drugs, which include hormones and vaccines. Table 1 illustrates some of the leading biopharmaceutical therapy classes by size worldwide in 2002. In 2008 approximately 39%, among the top 10 drugs sold globally, are biopharmaceuticals and is expected to rise to 79% of the top 10 drug sales by 20 14.[8] Table.1: Leading biopharmaceutical therapy classes by size worldwide 2002. Source: IMS MIDAS December 2002. However after the post recession period, fundings over health care and other sector is reduced which impede the growth rate of pharmaceutical industries up to significant extent. Although biopharmaceutical global sales thrive to attain high numbers in the global health sector. Biotechnological based products have generated $229 billion revenue in 2012 with an annual growth rate of 10.4%. Meanwhile the major focus of pharmaceutical organizations is on biopharmaceutical vs. Small molecule drugs which enables to allocate high funding towards this area. This may be due to very less generic biosimilar products available in the market. In year 2009 there are total 18 biopharmaceutical products are approved by US FDA which is higher than the previous years i.e. 11 in 2008 and 10 in 2007. In a report of Battelle Technology Partnership Practice, it was estimated that the overall impact of biopharmaceutical sector on the US economy is $917 billion. These companies are making alliances with oth er essential services such as computing and information, clinical trial and regulatory support services, technologies, manufacturing and equipment, and transportation and logistics providers.[9-11] Types of Biopharmaceuticals Cytokines Cytokines are a diverse group of non-antibody intercellular signalling regulatory proteins i.e. glycoprotein and low molecular weight peptides produced in very little amount inside the body. They function as a mediator for communication between various cells and induce certain response by binding to specific cell surface receptors which results in triggering various intracellular signal transduction mechanism. There are over 80 sub class of cytokines have been found. Some of these are categorized in table 2. They play an important role in coordinating embryonic development, cell growth and maturation, wound repair and healing, the immune response including acute phase reactions and septic shock, and new blood vessel formation. Cancer is among the major class of disease which is thoroughly scrutinized by the researchers with an emphasis on cytokines. However cytokines also play a vital role in mediating signalling response to systemic inflammation which tends to regulate specific neur onal network to induce sickness. Some animal studies reveal the role of cytokines in situations characterized by abnormal sleep, with emphasis on the pathogenesis of symptoms and consequences of OSAS (Obstructive sleep apnoea syndrome). Cytokines interact with specific cells via (1) intracrine, in which both cytokine and receptor remain within the cell (rare); (2) autocrine, where a cytokine acts on the receptors of the same cell it is produced; and (3) paracrine, where the cytokine from one cell type interacts with receptors on other cell types.[12-16] Table 2: categorization of cytokines. There are various cytokines products available in the market and some of them are reviewed under the clinical phase for example Interleukin-2 (IL-2) aldesleukin (Proleukin), for treating renal cell carcinoma is approved by FDA. IL-1 blocker, anakinra (Kineret) and rilonacept (Arcalyst) are used for the treatment of rheumatoid arthritis and cryopyrin-associated periodic syndromes respectively.[1] Enzymes Enzymes are complex molecules produced by living cells. They increase the rate of chemical reaction without even showing their own effect in the process and hence act as a catalyst in living organisms.[17] Because of their reaction specificity, catalytic efficiency and ability to operate under mild condition of temperature and hydrogen ion concentration they are preferred as a novel class of therapeutic agents. Despite of their therapeutic role enzyme endures significant importance as a replacement therapy in many genetic disorders. However there are some disadvantages as well associated with their use such as, their parental administration required extensive purification to remove contaminants. They are also very costly to prepare and due to their large molecular structure they have limited distribution in the body. As they are proteins hence when administered inside the body act as antigen to the host cell.[18,19] Enzymes are categorized under six major classes i.e transferases, lysases, hydrolases, isomerases, ligases, and oxidoreductases. The potential utility of enzyme as pharmaceutical was noted many decades ago. However most of the enzyme therapies are used to treat functional defects. Activase ® (alteplase; recombinant human tissue plasminogen activator), is the first recombinant enzyme drug which was approved by the Food and Drug Administration in 1987. Pulmozyme ® (Dornase alpha), a recombinant DNAse I that digests DNA in the mucous secretions in lungs, used to treat cystic fibrosis. Adagen ® (pegadamase bovine), is the first marketed product as enzyme therapy for the treatment of SCID (severe combined immunodeficiency disease).[20] Hormones Hormone is characterized as an important group of regulatory molecule which is synthesized in an organ or in tissue and then secreted into circulatory system where it affects respective organs whose cell bears an appropriate receptors. They are chemical messengers either small or a large macromolecule and are fairly defined as endocrine hormones. Approximately all endocrine hormones possess therapeutic importance and hence subsequently used by the researchers e.g. insulin(Insugen ®, Humulin ®, Novolin ®), human growth hormone (Ascellacrin ®, Crescormon ®), glucagon, and the gonadotrophins.[1] Antibodies: Antibodies or immunoglobulin are proteins produced, as an immune response, through white blood cells when a foreign particle or antigen intrudes inside the body. There are five classes of immunoglobulin IgE, IgM, IgG, IgD, and IgA. Amongst them IgG is the most common as a biopharmaceutical agents. A more specified term i.e. monoclonal antibodies (mAb  or  moAb) are the novel class compounds that are first developed in mid 1970s by kohler and Milstein, who successfully fused immortal cells with antibody- producing B lymphocytes. This fusion results in a hybrid which is stable, cancerous, antibody- producing cells. These are referred as hybridoma cells which unveil great source of monoclonal antibody. mAb identify antigens on a particular foreign body very specifically. mAbs are categorized under four groups according to their source: murine (derived solely from mice), chimeric (mixture of murine and human sequences), humanised (contain over 90% human sequences) and fully human.[8, 17] In 1986, Murobmonab (OKT3), a murine antibody, is the first monoclonal antibody tested as a therapeutic in humans. However it fails to produce a substantial response in the transplantation rejection patients because of production of anti-murine antibody.[20] Monoclonal antibodies are the fastest growing therapeutic class in the field of biopharmaceutical market. The market of monoclonal antibodies crosses the mark of $30 billion in 2011. Infliximab (Remicade) is the top selling monoclonal antibody in 2002 which was developed by Centocor and is marketed by Centocor and Schering-Plough for the treatment of rheumatoid arthritis (RA) and Crohns disease. Rituximab (Rituxan), developed by Genentech and IDEC and marketed by Genentech, IDEC and Roche, for the treatment of non-Hodgkins lymphoma, is the second largest selling monoclonal antibody.[21] Vaccines: Vaccines are antigenic proteins which are either partial or modified form of bacteria, viruses and toxins which causes certain diseases against which vaccine protects. The antigenic property of vaccines is altered from its original form by certain processes such as utilizing attenuated viruses, inactivated viruses, part of a virus or bacteria and toxin produced by bacteria; hence they lack ability to cause disease although, endures ability to produce an immune response.[22] Vaccines are the only known prophylactic approach which are commonly available to cure many infective diseases. Vaccines cover the global market share of $ 3 billion annually. Government health agencies run different immunization programs which alleviate the risk of many infective disorders. However, there are approximately 15 million people die every year from certain infectious diseases that can be cured by vaccination process. Pharmaceutical and biopharmaceutical industries seek great potential in this area but the use is limited because of their high production cost, delivery and distribution problems. Vaccines may contain animal derived products such as Bovine serum albumin or fetal calf serum or human derived product for example using cell lines of human tissues. However in recent years transgenic and recombinant plants are also utilized for the production of vaccines.[12,23,24] There are different vaccines available in the market for many infectious diseases such as poliomyelitis, cholera, diphtheria, tetanus, hepatitis B, hepatitis A, measles, meningitis etc. For hepatitis B virus some examples are Baraclude (Entecavir ®), Adefovir dipivoxil (Hepsera ®), Lamivudine (Epivir ®-HBV, 3TC), Alfa Interferon (Intron ® A, Infergen ®, Roferon ®).[1,25] Antisense drugs: Antisense compounds are non-coding strand of messenger RNA(mRNA), which hybridize with mRNA and inactivates the ability of genes to produce the protein for which it holds the recipe.[26] They do not alter human gene causing variation in human genetic information. It was first developed in 1978 using a string of DNA nucleotide which binds with messenger RNA and block its function. These drugs are designed to treat a wide range of diseases such inflammatory, infectious, cancer and cardiovascular diseases. Fomiversen was the first antisense drug approved in 1998 for the treatment of cytomegalovirus retinits in AIDS patients. These are categorized under three sub-classes i.e. antisense oligonucleotides(ASONs), ribozymes and RNA interference(RNAi). Affinitak, manufactured by ISIS pharmaceuticals and Eli Lilly, is used for the treatment of non-small-cell lung carcinoma(NSCLC). There are certain antisense compound are under review by health agencies for their therapeutic efficacy towards ma ny anomalies[27,28] Peptide therapeutics: Peptides are polymers having one or two amino acids linked with amides and are chemically synthesized by using liquid phase or solid phase synthesis. Their chemical synthesis is preferred over biosynthetic approach because it facilitates the conjugation or incorporation of small molecules and non-natural amino acids. This approach reveals the potential of such molecules as cytotoxic agents for antitumor therapy. Peptides with non-natural opens up the possibility for greater chemical diversity, analogous to small-molecule medicinal chemistry approaches for developing high-af ¬Ã‚ nity, highspeci ¬Ã‚ city molecular recognition. Cationic antimicrobial peptides (CAMPs) and peptidoglycan recognition proteins (PGRPs)are developed from the effectors of innate immune response in eukaryotes during their defense mechanism. However there are not many products of peptides found in the market but researchers are trying to develop some therapeutic peptides and proteins with significant effect towards certain diseases. Nesiritide (Natrecor, Noratak) is produced by Johnson Johnson2001, Teriparatide (Forteo) is developed and marketed by Lily in 2002 Enfuvirtide (Fuzeon) is manufactured by Trimeris 2003.[29-31] Challenges associated with biopharmaceutical products: Biopharmaceutical products such as monoclonal antibodies, vaccines, certain hormones, and cell therapies are rewarded as some of the most promising innovation in the field of medicine and health. However there are certain risk and challenges associated with such products which hamper their performance. One of the major challenges is the purification of proteins although it can be achieved by various processes but still purification of such compound is very critical hence requires a lot of attention during manufacturing. Next generation pharmaceutical.[32] However the whole process is carried out under two phases i.e. upstream and downstream regulation. Immunogenicity associated with some of these proteins is also a major concern for biopharmaceutical agents. A repeated injection of human protein may affect the immune tolerance towards self- antigen, leading to humoral response.[33]   Biopharmaceutical products require greater attention, process level as well as monitory level, in the development phase of the drug discovery process it requires approximately $200 million to develop a biopharmaceutical product hence the risk associated with their failure during development stage is increased. Apart from purification and immunogenicity some other issues also make some impact during their development such as government regulations which influence the cost of such products. As discussed earlier it takes a large amount of money to develop such agents hence companies also compensate their development cost and earn profits from their products, ones marketed, which exponentially increases the cost of the drugs. Last and one of the most important risk associated with such products is the introduction of biosimilar products. Biopharmaceutical market is growing very fast, the initial compounds of the first generation are now coming to an end. The expiry of the patents opens the market for generic products which not only influence the established market of some very popular brands, it also forms a milieu of competition to sell the products at cheaper rates which is compensated by their quality.[34] Conclusion Biopharmaceutical products are one amongst the novel class of therapeutic compounds. These are medical agents obtained from biological sources and some special one are manufactured by biotechnological means. They are cellular products, therapeutic proteins, vaccines, gene therapy products and plasma blood product derivatives. Erythropoietins, insulins, and monoclonal antibodies, are some of the leading biopharmaceutical products available in the market hence biopharmaceutical companies are now focusing on their use in long-term conditions such as cardiovascular disease, diabetes and asthma. The blockbuster sales of some existing biopharmaceutical products accompanied by the tremendous innovation and a plethora of pipeline products demonstrate the vigorous growth in the biopharmaceutical market in upcoming years. This significant growth is supported by some of the key segments of the field like monoclonal antibody and vaccines. In addition approaches like gene therapy and peptide ther apeutics holds enormous potential for some life threatening anomalies and the combined approach of proteomics, genomics and biotechnology is predicted to empower the most part of the healthcare sector in the upcoming days.

Microsoft’s MACH Program Designed to Help Millennial Grads Make a Difference †Fast Essay

The Microsoft Academy for College Hires (MACH) is as an accelerated career development program designed to recruit and hire top-performing graduates across a broad range of roles, and aims to cultivate talent utilizing training, mentoring, and community support. Microsoft believes that work is a place for exploration, creativity, innovation and professional growth. It’s about being inspired and motivated to achieve extraordinary things that leave a lasting impact. At Microsoft, graduates learn from the finest in the business. As a full time graduate employee, they experience an inspiring world-class program. MACH participants are hired based on potential and are provided with a comprehensive on-boarding curriculum, enabling them to accelerate their careers and become part of the next generation of key contributors and leaders. Microsoft will be invested in your career development and provide guidance and support to enable you to excel in your Microsoft career. The two year pro gram is focused on ensuring that graduates receive the professional development early to help them accelerate the impact in role and that they have the tools and knowledge to steer long term career. With over 2,500 MACH employees in over 60 countries worldwide, graduates gain a network to a global community of peers, leadership exposure, world class trainings and the opportunity to take on challenging work that contributes meaningfully to helping people and businesses realize their full potential. Questions †¢How does orientation differ from onboarding? Orientation is the formal process of familiarizing new employees with the organization, their jobs, and their work units, while onboarding is the process of systematically socializing new employees to help them get â€Å"on board† with an organization. Orientation is a timed event. It usually lasts a day (or less if you do it well) and is an opportunity to share a lot of information that employees should know. For example: Where the bathrooms are; what time everyone takes lunch; Where to park to avoid being towed. Orientation is meant to share the essentials. It is intended to ensure that new hires get the very basics of what they have and usually includes a lot of paperwork filling out time. It is not very interactive and certainly does not help the new hire after it is over. Onboarding is much longer. It takes  place both before and after the hire. It could last weeks or months – the longer the better. It is meant to introduce and ingrain the company culture and way of working. It should reinforce everything the new hire was told in the recruiting phase. It should incentivize new hires to do their best work until they can do better. Then it should incentivize them to do better. It should make them happy with their decision. It should develop, coach and mentor. It should turn a great hire into a great employee. †¢Why do you think Microsoft implemented the MACH program? Can you see any drawbacks of doing so? Microsoft Academy for College Hires (MACH) is a two-year program designed to provide new university graduates hired into the company’s sales, marketing, and services divisions with onboarding courses, hands-on training, coaching and networking opportunities. The main objective of MACH is not only to onboard new graduates so they can start adding value to their teams quickly, but to help them more efficiently navigate the corporate culture and politics. MACH has help numerous graduates maneuver throughout the corporate world by helping them build network with senior employees and also to connect with other Microsoft employees around the world. Microsoft Academy for College Hires is an excellent idea, especially in today’s economy. If more large companies such as Microsoft developed a program as this, new graduates joining the work force will be more comfortable, more engaged in what they want to do and their specialties. The program teaches networking and corporate skill s these graduates will take throughout life. The only drawback the program may entail is the mentors scheduling. Once new hires beginning observing a mentor, it is more beneficial for them to remain with their mentor for the duration of the program. Switching between mentors has its positives and negatives and lost of interest and personality adjustments are a few negatives that may be included. †¢How might the program improve Microsoft’s employer brand and help it attract talent? Joseph Ibarra, a MACH 2008 graduate, is a supporter of the program. â€Å"I’ve seen alumni at the MACH events, people who have accelerated quickly throughout the company and won some of Microsoft’s most prestigious awards. It’s really inspirational to see people come to the company and have  a huge influence. It shows it can be done, even at a company with so many people.† Graduates of the Microsoft Academy for College Hires (MACH) are perfect advertisement for Microsoft. The positive enrichment and development that the graduates have received are perfect for Microsoft to use to engage other soon to be graduates to the company. These graduates that are currently apart of the MACH program are also perfect candidates to become apart of the growing company. Since Microsoft have invested time and money into the development and training of these graduates, employing them within the company will be a positive give back to the company and the program itself. REFERENCE: †¢Snell, S., & Bohlander, G. W. (2013). Managing human resources (16th Ed), Mason, Ohio: South-Western Cengage Learning †¢Microsoft Careers: MACH Program. (n.d.). Retrieved from http://careers.microsoft.com/careers/en/nz/mach.aspx

Essay on Gun Ownership and the Second Amendment of the...

Gun Ownership and the Second Amendment Over the centuries, the Supreme Court has always ruled that the 2nd Amendment protects the states militias rights to bear arms, and that this protection does not extend to individuals. In fact, legal scholars consider the issue settled law. For this reason, the gun lobby does not fight for its perceived constitutional right to keep and bear arms before the Supreme Court, but in Congress. Interestingly, even interpreting an individual right in the 2nd Amendment presents the gun lobby with some thorny problems, like the right to keep and bear nuclear weapons. The Second Amendment states: A well-regulated militia being necessary to the security of a free state, the right of the people†¦show more content†¦The reason is because the Supreme Court -- this nations final arbiter on the interpretation of the Constitution -- has always ruled that the Second Amendment does not extend the right to keep and bear arms to individuals, but to the well-regulated militias mentioned in the first part of the amendment. Specifically, these are militias that are regulated by the federal and state governments. Article I, Section 8 authorizes Congress: To provide for calling forth the militia to execute the laws of the union, suppress insurrections and repel invasions; to provide for organizing, arming and disciplining the militia, and for governing such part of them as may be employed in the service of the United States, reserving to the states respectively the appointment of officers, and the authority of training the militia according to the discipline prescribed by Congress. The Founders were passionately opposed to standing peacetime armies -- in fact, Thomas Jefferson listed it as one of their grievances against the British Crown in the Declaration of Independence. Intent on eliminating this evil, they created a system whereby citizens kept their arms at home and could be called by their state militias at a moments notice. 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First Battle of Bull Run

The Battle of Bull Run was the first major battle of the American Civil War, and it occurred, in the summer of 1861, when many people believed the war would probably only consist of one big decisive battle. The battle, which was fought in the heat of a July day in Virginia, had been carefully planned by generals on both the Union and Confederate sides. And when inexperienced troops were called upon to execute the fairly complicated battle plans, the day turned chaotic. While it looked for a time like the Confederates would lose the battle, a fierce counterattack against the Union Army resulted in a rout. By the end of the day thousands of demoralized Union troops were streaming back to Washington, D.C., and the battle was generally seen as a disaster for the Union. And the failure of the Union Army to secure a quick and decisive victory made it clear to Americans on both sides of the conflict that the Civil War would not be the short and simple affair many assumed it would be. Events Leading to the Battle After the attack on Fort Sumter in April 1861, President Abraham Lincoln issued a call for 75,000 volunteer troops to come from the states which hadn’t seceded from the Union. The volunteer soldiers enlisted for a term of three months. Troops began arriving in Washington, D.C. in May 1861, and set up defenses around the city. And in late May portions of northern Virginia (which had seceded from the Union after the attack on Fort Sumter) were invaded by the Union Army. The Confederacy set up its capital in Richmond, Virginia, about 100 miles from the federal capital city, Washington, D.C. And with northern newspapers trumpeting  the slogan  Ã¢â‚¬Å"On to Richmond,† it seemed inevitable that  a  clash would occur somewhere between Richmond and Washington in that first summer of war. Confederates Massed In Virginia A Confederate army began massing in the vicinity of Manassas, Virginia, a railroad junction situated between Richmond and Washington. And it became increasingly obvious that the Union Army would be marching south to engage the Confederates. The timing of precisely  when the battle would be fought became a complicated issue. General Irvin McDowell had become the leader of the Union Army, as General Winfield Scott, who had commanded the army, was too old and infirm to command during wartime. And McDowell, a West Point graduate and career soldier who had served in the Mexican War, wanted to wait before committing his inexperienced troops to battle. President Lincoln saw things differently. He was well aware that the enlistments for the volunteers was only for three months, which meant most of them could be going home before they ever saw the enemy. Lincoln pressed McDowell to attack. McDowell organized his 35,000 troops, the largest army ever assembled in North America to that time. And in mid-July he began moving toward Manassas, where 21,000 Confederates had assembled. The March to Manassas The Union Army began moving south on July 16, 1861. Progress was slow in the July heat, and the lack of discipline of many of the new troops didn’t help matters. It took days to reach the area of Manassas, about 25 miles from Washington. It became clear that the anticipated battle would take place on Sunday, July 21, 1861. Stories would often be told about how spectators from Washington, riding in carriages and bringing along picnic baskets, had raced down to the area so they could watch the battle as if it was a sporting event. The Battle of Bull Run General McDowell conceived a fairly elaborate plan to attack the Confederate army commanded by his former West Point classmate, General P.G.T. Beauregard. For his part, Beauregard also had a complex plan. In the end, the plans of both generals fell apart, and actions by individual commanders and small units of soldiers determined the outcome. In the early phase of the battle the Union Army seemed to be beating the disorganized Confederates, but the rebel army managed to rally. General Thomas J. Jackson’s brigade of Virginians helped turn the tide of the battle, and Jackson that day received the everlasting nickname â€Å"Stonewall† Jackson. Counterattacks by Confederates were helped by fresh troops who arrived by railroad, something entirely new in warfare. And by late afternoon the Union Army was in retreat. The road back to Washington became a scene of panic, as the frightened civilians who had come out to watch the battle tried to race homeward alongside thousands of demoralized Union troops. Significance of the Battle of Bull Run Perhaps the most important lesson from the Battle of Bull Run was that it helped erase the popular notion that the rebellion of the slave states would be a short affair settled with one decisive blow. As an engagement between two untested and inexperienced armies, the battle itself was marked by countless mistakes. Yet two sides demonstrated that they could put large armies in the field and could fight. The Union side sustained casualties of about 3,000 killed and wounded, and Confederate losses were about 2,000 killed and wounded. Considering the size of the armies that day, the casualties were not heavy. And casualties of later battles, such as Shiloh and Antietam the following year, would be far heavier. And while the Battle of Bull Run didn’t really change anything in a tangible sense, as the two armies essentially wound up in the same positions as where they had started, it was a powerful blow to the pride of the Union. Northern newspapers, which had bellowed for a march into Virginia, actively looked for scapegoats. In the South, the Battle of Bull Run was considered a great boost to morale. And, as the disorganized Union Army had left behind a number of cannon, rifles, and other supplies, just the acquisition of material was helpful to the Confederate cause. In an odd twist of history and geography, the two armies would meet about a year later in essentially the same place, and there would be a Second Battle of Bull Run, otherwise known as the Battle of Second Manassas. And the outcome would be the same, the Union Army would be defeated.